ICM Research in Focus – Chromosomal instability

March 22, 2023

In this week’s episode, Professor Florian Markowetz talks about his work and recent publication on chromosomal instability. Chromosomal instability is a dynamic process of DNA change, which leads to some DNA being present multiple times and some being lost altogether. Some cancers are dominated by this process of genomic disruption; ovarian, pancreatic and triple-negative breast cancer for example. These chaotic DNA changes mean that there are not good biomarkers present to guide treatment decisions. Florian’s laboratory has found a structure underlying chromosomal instability and has identified genomic fingerprints which enable them to read out the fundamental reasons for the DNA changes.

Florian is Group Leader at the Cancer Research UK Cambridge Institute at the University of Cambridge

ICM Research in Focus – Chromosomal instability
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